Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair. Issue 2 (6th July 2018)

• Record Type: Journal Article
• Authors: Garikipati, Venkata Naga Srikanth; Shoja-Taheri, Farnaz; Davis, Michael E.; Kishore, Raj
• Is Part Of: Circulation research. Volume 123:Issue 2(2018)
• Publication Date: 2018-07-06
• Subjects: biology -- exosomes -- extracellular vesicles -- lipids -- stem cells; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.117.311215
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : Recent literature suggests that extracellular vesicles (EVs), secreted from most cells and containing cell-specific cargo of proteins, lipids, and nucleic acids, are major driver of intracellular communication in normal physiology and pathological conditions. The recent evidence on stem/progenitor cell EVs as potential therapeutic modality mimicking their parental cell function is exciting because EVs could possibly be used as a surrogate for the stem cell–based therapy, and this regimen may overcome certain roadblocks identified with the use of stem/progenitor cell themselves. This review provides a comprehensive update on our understanding on the role of EVs in cardiac repair and emphasizes the applications of stem/progenitor cell–derived EVs as therapeutics and discusses the current challenges associated with the EV therapy.