Case series of multiple primary cancers in single individuals: diagnostic and therapeutic dilemmas. Issue 4 (2nd October 2017)

• Record Type: Journal Article
• Authors: Malik, Faizan; Ali, Naveed; Durrani, Jibran; Mustafa, Syed Imran; Denlinger, Crystal
• Is Part Of: Journal of community hospital internal medicine perspectives. Volume 7:Issue 4(2017)
• Page Start: 238
• Page End: 240
• Publication Date: 2017-10-02
• Subjects: Multiple cancers -- field cancerization -- esophageal cancer -- colon cancer -- carcinoid tumors; Internal medicine -- Periodicals; Hospitals -- Periodicals; Hospitals, Community; Internal Medicine; Hospitals; Internal medicine; Periodicals; Periodicals; 610
• DOI: 10.1080/20009666.2017.1369377
• Languages: English
• ISSNs: 2000-9666

Abstract

ABSTRACT: Background and Objectives : Cancer recurrence represents treatment failure; the development of new primary tumors is suggestive of persistent exposure to etiological risk factors or genetic predisposition due to mutations in multiple cell lines. Case presentation/Design/Methods : The first case is a 65-years-old Caucasian male who presented with esophageal and lung cancer diagnosed synchronously. Smoking was the common risk factor for both cancers, underscoring field cancerization. The diagnosis and management was a challenge and different from either cancer presenting alone. Multidisciplinary approach was used and led to good outcomes. The second case is a 72-years-old Caucasian male presenting a rare dilemma of genetic mutation leading to multiple primary gastrointestinal cancers in a single individual. The gene explaining this group of cancers has not been diagnosed yet and the field needs to be explored further. Conclusion : Multiple primary cancers can be secondary to a common environmental risk factor or genetic mutations.