Cognitive impairment and morphological changes after radiation therapy in brain tumors: A review. Issue 2 (August 2018)

• Record Type: Journal Article
• Authors: Jacob, Julian; Durand, Thomas; Feuvret, Loïc; Mazeron, Jean-Jacques; Delattre, Jean-Yves; Hoang-Xuan, Khê; Psimaras, Dimitri; Douzane, Hassen; Ribeiro, Monica; Capelle, Laurent; Carpentier, Alexandre; Ricard, Damien; Maingon, Philippe
• Is Part Of: Radiotherapy and oncology. Volume 128:Issue 2(2018)
• Page Start: 221
• Page End: 228
• Publication Date: 2018-08
• Subjects: AD axial diffusivity -- ADC apparent diffusion coefficient -- BED biologically equivalent doses -- CT computed tomography -- DTI diffuse tensor imaging -- FA fractional anisotropy -- FDG 18F-fluorodeoxyglucose -- gEUD generalized uniform equivalent dose -- HGG high-grade gliomas -- HVLT-R Hopkins Verbal Learning Test-Revised -- IMRT intensity modulated radiotherapy -- LGG low-grade gliomas -- MD mean diffusivity -- MRI magnetic resonance imaging -- NSC neural stem cells -- PRV planning-at-risk volume -- PTV planning target volume -- RD radial diffusivity -- SVZ subventricular zones -- WBRT whole-brain radiation therapy -- WM white matter; Brain -- Radiotherapy -- Cognition -- Toxicity -- Radiosensitivity; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2018.05.027
• Languages: English
• ISSNs: 0167-8140

Abstract

Abstract: Life expectancy of patients treated for brain tumors has lengthened due to the therapeutic improvements. Cognitive impairment has been described following brain radiotherapy, but the mechanisms leading to this adverse event remain mostly unknown. Technical evolutions aim at enhancing the therapeutic ratio. Sparing of the healthy tissues has been improved using various approaches; however, few dose constraints have been established regarding brain structures associated with cognitive functions. The aims of this literature review are to report the main brain areas involved in cognitive adverse effects induced by radiotherapy as described in literature, to better understand brain radiosensitivity and to describe potential future improvements.