Effects of Dangguisusan, a prescription of Korean medicine on controlled cortical impact-induced traumatic brain injury mouse model. (28th October 2018)

• Record Type: Journal Article
• Authors: Jung, Jae-Young; Joo, Hyejin; Bae, Jinhyun; Bang, Yumi; Lee, Beom-Joon; Cho, Jae-Heung; Park, Jae-Woo; Lee, Kyungjin; Bu, Youngmin
• Is Part Of: Journal of ethnopharmacology. Volume 225(2018)
• Page Start: 198
• Page End: 201
• Publication Date: 2018-10-28
• Subjects: TBI Traumatic brain injury -- DGSS Dangguisusan -- NOR Novel object recognition -- DW Distilled water -- BW Body weight; Dangguisusan -- Traumatic brain injury -- Controlled cortical impact -- Sensory-motor function -- Cognitive function; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2018.07.015
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Dangguisusan (DGSS) is a widely used prescription for the treatment of traumatic injury in Korean medicine. Aim of the study: To demonstrate the effects of DGSS on a mouse model of traumatic brain injury (TBI) for providing scientific evidence in clinical use. Materials and methods: TBI was induced in a mouse model using the controlled cortical impact method. Water extract of DGSS (50, 150, and 450 mg/kg) was administered twice a day for 8 d. Histological analyses were performed 8 d after TBI. Moreover, beam-walking, grip-strength, and novel object recognition (NOR) tests were conducted to evaluate the effects on motor function, muscle strength, and cognitive memory function, respectively. Result: DGSS inhibited body weight loss, hippocampal damage, and neuronal loss in the thalamic region. Furthermore, it reduced transverse time and foot faults in the beam-walking test at 3 d and increased the muscle strength in the grip-strength test at 3 and 8 d. It also improved the recognition index (%) in the NOR test. However, DGSS did not show protective effects against total damage. Conclusions: DGSS might improve sensory–motor and cognitive functions after TBI with partial protective effects against brain damage. The present findings provide a scientific basis for the clinical use of DGSS in TBI. Graphical abstract: