The role of interleukin‐4 in rheumatic diseases. (20th May 2018)

• Record Type: Journal Article
• Authors: Dong, Chen; Fu, Ting; Ji, Juan; Li, Zhenyu; Gu, Zhifeng
• Is Part Of: Clinical and experimental pharmacology and physiology. Volume 45:Number 8(2018)
• Page Start: 747
• Page End: 754
• Publication Date: 2018-05-20
• Subjects: inflammation -- interleukin‐4 -- rheumatic diseases; Clinical pharmacology -- Periodicals; Pharmacology, Experimental -- Periodicals; Physiology, Experimental -- Periodicals; Physiology, Pathological -- Periodicals; 615.1
• DOI: 10.1111/1440-1681.12946
• Languages: English
• ISSNs: 0305-1870

Abstract

Summary: Rheumatism is a group of diseases, most of which are autoimmune diseases, that violate joints, bones, muscles, blood vessels and related soft tissue. As is well known, cytokines play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, and systemic lupus erythematosus. Recently, the role of interleukin‐4 (IL‐4), which may participate in the mechanism of rheumatism, have been discovered. It is reported that IL‐4 takes part in the regulation of T cell activation, differentiation, proliferation, and survival of different T cell types. IL‐4 also has an immunomodulatory effect on B cells, mast cells, macrophages, and many cell types. A review of the literature on functions of IL‐4 in rheumatic diseases is presented.