Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector. (16th July 2018)

• Record Type: Journal Article
• Authors: Sakai, Madoka; Ueda, Sakiho; Daito, Takuji; Asada‐Utsugi, Megumi; Komatsu, Yumiko; Kinoshita, Ayae; Maki, Takakuni; Kuzuya, Akira; Takahashi, Ryosuke; Makino, Akiko; Tomonaga, Keizo
• Is Part Of: Microbiology and immunology. Volume 62:Number 7(2018)
• Page Start: 467
• Page End: 472
• Publication Date: 2018-07-16
• Subjects: Alzheimer disease -- amyloid β -- Borna disease virus vector -- neprilysin; Microbiology -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Microbiologie -- Périodiques; Immunologie -- Périodiques; 579
• DOI: 10.1111/1348-0421.12602
• Languages: English
• ISSNs: 0385-5600

Abstract

ABSTRACT: Accumulation of amyloid β (Aβ40 and Aβ42) in the brain is a characteristic of Alzheimer disease (AD). Because neprilysin (NEP) is a major Aβ‐degrading enzyme, NEP delivery in the brain is a promising gene therapy for AD. Borna disease virus (BoDV) vector enables long‐term transduction of foreign genes in the central nerve system. Here, the proteolytic ability of NEP transduced by the BoDV vector was evaluated and it was found that the amounts of Aβ40 and Aβ42 decreased significantly, suggesting that NEP expressed from the BoDV vector is functional in that it degrades Aβ.