Regulation of immune cell signaling by activated protein C. Issue 6 (30th March 2018)

• Record Type: Journal Article
• Authors: Healy, Laura D.; Rigg, Rachel A.; Griffin, John H.; McCarty, Owen J. T.
• Other Names: Wallet Mark guestEditor.; Justement Lou guestEditor.; Bishop Gail guestEditor.; Rane Madhavi guestEditor.; Iragavarapu‐Charyulu Vijaya guestEditor.
• Is Part Of: Journal of leukocyte biology. Volume 103:Issue 6(2018)
• Page Start: 1197
• Page End: 1203
• Publication Date: 2018-03-30
• Subjects: activated protein C -- APC -- EPCR -- Mac‐1 -- neutrophils -- PAR1 -- PAR3 -- sepsis; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.3MIR0817-338R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Innate immune cells are an essential part of the host defense response, promoting inflammation through release of proinflammatory cytokines or formation of neutrophil extracellular traps. While these processes are important for defense against infectious agents or injury, aberrant activation potentiates pathologic inflammatory disease. Thus, understanding regulatory mechanisms that limit neutrophil extracellular traps formation and cytokine release is of therapeutic interest for targeting pathologic diseases. Activated protein C is an endogenous serine protease with anticoagulant activity as well as anti‐inflammatory and cytoprotective functions, the latter of which are mediated through binding cell surface receptors and inducing intracellular signaling. In this review, we discuss certain leukocyte functions, namely neutrophil extracellular traps formation and cytokine release, and the inhibition of these processes by activated protein C. Abstract : Review on select leukocytic functions and how they are regulated by the anti‐inflammatory protease, activated protein C.