Cancer Therapy: Dual Intratumoral Redox/Enzyme‐Responsive NO‐Releasing Nanomedicine for the Specific, High‐Efficacy, and Low‐Toxic Cancer Therapy (Adv. Mater. 30/2018). Issue 30 (23rd July 2018)

• Record Type: Journal Article
• Authors: Jia, Xiaobo; Zhang, Yihua; Zou, Yu; Wang, Yao; Niu, Dechao; He, Qianjun; Huang, Zhangjian; Zhu, Weihong; Tian, He; Shi, Jianlin; Li, Yongsheng
• Is Part Of: Advanced materials. Volume 30:Issue 30(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-07-23
• Subjects: dual‐responsiveness -- nitric oxide -- prodrug delivery -- safe treatment -- tumor therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201870217
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : In article number1704490, Zhangjian Huang, Yongsheng Li, and co‐workers demonstrate a paradigm of dual intratumoral redox/enzyme‐responsive NO‐release nanomedicine for tumor‐specific and high‐efficacy cancer therapy by constructing a novel organic‐inorganic composite nanomedicine through encapsulating a GSTπ‐responsive NO‐releasing prodrug, NPQ, into a redox‐responsive organosilica nanocarrier, realizing the intratumoral GSH‐responsive organosilica biodegradation and subsequent controlled release of NO in response to intratumoral GSTπ.