Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables. (3rd May 2018)

• Record Type: Journal Article
• Authors: Sanchez‐Moreno, J.; Bonnin, C. M.; González‐Pinto, A.; Amann, B. L.; Solé, B.; Balanzá‐Martinez, V.; Arango, C.; Jiménez, E.; Tabarés‐Seisdedos, R.; Garcia‐Portilla, M. P.; Ibáñez, A.; Crespo, J. M.; Ayuso‐Mateos, J. L.; Martinez‐Aran, A.; Torrent, C.; Vieta, E.
• Other Names: Alegría Analucía investigator.; Al‐Halabi Susana investigator.; Alonso‐Lana Silvia investigator.; Anaya Celia investigator.; López Purificación investigator.; Bobes Julio investigator.; Chiclana Guadalupe investigator.; Cerrillo Esther investigator.; Correa Patricia investigator.; Custal Núria investigator.; Fernández Patricia investigator.; García Sainza investigator.; Fuentes‐Durá Inmaculada investigator.; Galván Gonzalo investigator.; González‐Ortega Itxaso investigator.; Isella Sandra investigator.; Landín‐Romero Ramon investigator.; Menchón Manuel investigator.; Merchan‐Naranjo Jessica investigator.; Ortiz‐Gil Jordi investigator.; Pacchiarotti Isabella investigator.; Reyes Raquel investigator.; Rapado‐Castro Marta investigator.; Reinares Maria investigator.; Rodao Maria investigator.; Saiz Pilar A investigator.; Segura Bárbara investigator.; Selva‐Vera Gabriel investigator.; Saiz‐Ruiz Jerónimo investigator.; Soria Virginia investigator.; Zorrilla Iñaki investigator.; Valle Jesús investigator.; Valls Elia investigator.; Varo Cristina investigator.;
• Is Part Of: Acta psychiatrica Scandinavica. Volume 138:Number 2(2018)
• Page Start: 145
• Page End: 154
• Publication Date: 2018-05-03
• Subjects: bipolar disorder -- depressive symptoms -- functional impairment -- neurocognition; Psychiatry -- Periodicals; 616.89
• DOI: 10.1111/acps.12894
• Languages: English
• ISSNs: 0001-690X

Abstract

Abstract : Objective: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate‐severe levels of functional impairment. Methods: Two‐hundred and thirty‐nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery. Analyses involved preliminary Pearson bivariate correlations to identify sociodemographic and clinical variables associated with the FAST total score. Regarding neuropsychological variables, a principal component analysis (PCA) was performed to group the variables in orthogonal factors. Finally, a hierarchical multiple regression was run. Results: The best fitting model for the variables associated with functioning was a linear combination of gender, age, estimated IQ, Hamilton Depression Rating Scale (HAM‐D), number of previous manic episodes, Factor 1 and Factor 2 extracted from the PCA. The model, including all these previous variables, explained up to 29.4% of the observed variance. Conclusions: Male gender, older age, lower premorbid IQ, subdepressive symptoms, higher number of manic episodes, and lower performance in verbal memory, working memory, verbal fluency, and processing speed were associated with lower functioning in patients with BD.