Fetal vascular malperfusion, an update. Issue 7 (24th July 2018)

• Record Type: Journal Article
• Authors: Redline, Raymond W.; Ravishankar, Sanjita
• Other Names: Maroun Lisa guestEditor.; Olsen Tina guestEditor.
• Is Part Of: Apmis. Volume 126:Issue 7(2018)
• Page Start: 561
• Page End: 569
• Publication Date: 2018-07-24
• Subjects: Cerebral palsy -- fetal thrombotic vasculopathy -- fetal vascular malperfusion -- neonatal encephalopathy -- perinatal stroke -- placental pathology -- umbilical cord; Pathology -- Periodicals; Microbiology -- Periodicals; Immunology -- Periodicals; 572
• DOI: 10.1111/apm.12849
• Languages: English
• ISSNs: 0903-4641

Abstract

Abstract : Fetal vascular malperfusion is the most recent term applied to a group of placental lesions indicating reduced or absent perfusion of the villous parenchyma by the fetus. The most common etiology of malperfusion is umbilical cord obstruction leading to stasis, ischemia, and in some cases thrombosis. Other contributing factors may include maternal diabetes, fetal cardiac insufficiency or hyperviscosity, and inherited or acquired thrombophilias. Severe or high grade fetal vascular malperfusion is an important risk factor for adverse pregnancy outcomes including fetal growth restriction, fetal CNS injury, and stillbirth. Overall recurrence risk for subsequent pregnancies is low.