Benedict's solution/ vitamin C: An alternative catalytic protocol for the synthesis of regioselective‐1, 4‐disubstituted‐1H‐1, 2, 3‐triazoles at room temperature. (5th June 2018)

• Record Type: Journal Article
• Authors: Konwar, Manashjyoti; Hazarika, Roktopol; Ali, Abdul A.; Chetia, Mitali; Khupse, Nageshwar D.; Saikia, Prakash J.; Sarma, Diganta
• Is Part Of: Applied organometallic chemistry. Volume 32:Number 8(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-05
• Subjects: 1, 4‐disubstituted‐1H‐1, 2, 3‐triazole -- azide‐alkyne cycloaddition -- Benedict's solution -- vitamin C; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.4425
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : A novel and highly efficient method for the synthesis of 1, 4‐disubstituted‐ 1H ‐1, 2, 3‐triazoles by copper‐catalyzed azide‐alkyne cycloaddition has been developed. This economic and sustainable protocol uses a readily available Benedict's solution/Vitamin C catalyst system affording a wide range of 1, 4‐disubstituted‐ 1H ‐1, 2, 3‐triazoles under mild conditions. Abstract : Development of aqueous phase copper salt solution in synthetic organic chemistry at room temperature achieves a greater consequence now a day. Here, 1, 4‐disubstitued‐ 1H ‐1, 2, 3‐triazoles are synthesized in presence of Benedict's solution, which has a wide applications on biological and organic practical laboratories but unexplored in the field of research. Along with Vitamin C, Benedict's solution acts as an alternative catalytic system for the triazoles synthesis at room temperature and this leads to the environment benign methodology.