Increased monocyte-to-HDL cholesterol ratio is related to cardiac syndrome X. Issue 5 (3rd September 2017)

• Record Type: Journal Article
• Authors: Dogan, Adnan; Oylumlu, Muhammed
• Is Part Of: Acta cardiologica. Volume 72:Issue 5(2017)
• Page Start: 516
• Page End: 521
• Publication Date: 2017-09-03
• Subjects: Cardiac syndrome X -- inflammation markers -- monocyte-to-HDL cholesterol ratio; Cardiology -- Periodicals; Cardiology; Cardiologie -- Périodiques; Cardiology; Cardiologie; Periodicals; Periodicals; 616.12005
• DOI: 10.1080/00015385.2017.1299521
• Languages: English
• ISSNs: 0001-5385

Abstract

Abstract: Objective: Cardiac syndrome X (CSX) is typically identified with ischaemia in treadmill exercise test or stress myocardial perfusion scintigraphy as well as angina-like chest pain without stenosis in coronary angiography. The purpose of the present study is to investigate the association between cardiac syndrome X and monocyte-to-HDL cholesterol ratio (MHR) which is a new marker associated with inflammation. Patients and methods: A total of 230 patients (105 patients with cardiac syndrome X and 125 normal controls) were included in the study. Peripheral venous blood samples were drawn from all study population before coronary angiography for measuring MHR and other haematological parameters. Results: The patients with cardiac syndrome X were more likely to have higher platelet counts, plateletcrit (PCT), monocyte count and MHR values. Monocyte count and MHR of the CSX group were significantly higher than the control group [0.53 (0.35–1) vs. 0.49 (0.23–0.96); p = .002, .011 (0.006–0.038) vs. 0.010 (0.004–0.034); p < .001, respectively]. HDL-cholesterol levels of the CSX group were significantly lower than the control groups (46.3 ± 10.1 vs. 49.6 ± 11.6; p = .021). Higher MHR and PCT values were found to be associated with the presence of CSX by multivariate logistic regression analysis. Conclusions: Elevated MHR level independently was found in association with the presence of CSX. The value of MHR appears additive to conventional expensive methods commonly used in CSX prediction.