Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production. Issue 16 (18th August 2018)

• Record Type: Journal Article
• Authors: Yuan, Ting; Zhang, Cuiyun; Qiu, Chongyue; Xia, Guiyang; Wang, Fei; Lin, Bin; Li, Hua; Chen, Lixia
• Is Part Of: Natural product research. Volume 32:Issue 16(2018)
• Page Start: 1887
• Page End: 1892
• Publication Date: 2018-08-18
• Subjects: Curcuma longa L. -- sesquiterpenoids -- nitric oxide; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1354185
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new bisabolane-type sesquiterpenoid, turmerone Q (1 ), along with six known compounds (2–7 ), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using 1 H NMR, 13 C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of1 was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of1–7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds6 and7 showed potent inhibitory activity against NO production. Abstract :