Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury. Issue 16 (18th August 2018) - Bouratoua, Aicha
Abstract: This is the first study on the phytochemistry and antioxidant activity of Ferula longipes Coss. ex Bonnier and Maury (Apiaceae). A new flavonoid quercetin-3- O - α -L-rhamnopyranoside-7-O- ß -D-[2-O-caffeoyl]-glucopyranoside (1 ), along with 10 known compounds kaempferol-3- O - α -L-rhamnopyranoside (2 ), quercetin-3- O - α -L-rhamnopyranoside (3 ), kaempferol-3- O - ß -D-glucopyranoside-7- O - α -L-rhamnopyranoside (4 ), isorhamnetin-3- O - α -L-rhamnopyranoside-7- O - ß -D-glucopyranoside (5 ), quercetin-3- O - α -L-rhamnopyranoside-7- O - ß -D-glucopyranoside (6 ), isorhamnetin-3, 7-di- O - β -D-glucopyranoside (7 ), apigenin (8 ), apigenin-7- O - ß -D-glucopyranoside (9 ), 3, 5-dicaffeoylquinic acid (10 ), deltoin (11 ) were isolated from the aerial parts of Ferula longipes Coss. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data. The compounds1, 3, 4, 6, 7 and10 were evaluated for their antioxidant activity, compound1 exhibited the best antiradical activity potential and showed IC50 and A0.5 values 5.70, 7.25, 5.00, and 2.63 μg/mL towards DPPH free radical-scavenging, ABTS, CUPRAC, and reducing power assays, respectively compared with BHA, BHT and ascorbic acid which were used as positive controls. Abstract :