Chemical analysis and antiviral activity evaluation of Baccharis anomala. Issue 16 (18th August 2018)

• Record Type: Journal Article
• Authors: Venturi, Caroline Rita; Bordignon, Srgio Augusto De Loreto; Roehe, Paulo Michel; Montanha, Jarbas Alves; Cibulski, Samuel Paulo; Gosmann, Grace
• Is Part Of: Natural product research. Volume 32:Issue 16(2018)
• Page Start: 1960
• Page End: 1962
• Publication Date: 2018-08-18
• Subjects: Antiviral -- Baccharis anomala -- herpes simplex virus; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1354186
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The chemical composition and antiviral activity of aqueous extract from Baccharis anomala was studied by bioactivity-guided fractionation. Ethanol precipitation and fractionation by molecular permeation allowed the separation of the anti-herpes simplex virus 1 (HSV-1) active fraction from aqueous extract (Fraction B). Natural Product Reagent A, FeCl3 and thin-layer chromatography indicated the presence of phenolic compounds in the aqueous extract. Fraction B showed pronounced antiviral activity when tested with HSV-1 strains VR733/ATCC and Acyclovir-resistant 29-R, displaying virucidal but not virustatic activity. Abstract :