A DOX-loaded polymer micelle for effectively inhibiting cancer cells. Issue 46 (19th July 2018)

• Record Type: Journal Article
• Authors: Feng, Huayang; Chu, Dandan; Li, Zhanrong; Guo, Zhihua; Jin, Lin; Fan, Bingbing; Zhang, Junjie; Li, Jingguo
• Is Part Of: RSC advances. Volume 8:Issue 46(2018)
• Page Start: 25949
• Page End: 25954
• Publication Date: 2018-07-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra04089c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. Abstract : A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. The synthetic process involves the ring-opening polymerization, carboxylation and amidation reactions, and the structures are characterized. The drug release test indicated that the micelles have the ability to control the release of drugs. The cell uptake results indicated that the DOX-loaded micelles could enter cancer cells easily, and the cytotoxicity and apoptosis test confirmed that DOX-loaded micelles have a strong killing effect on tumor cells, while the blank micelles do not have cytotoxicity. Therefore, the novel polymer micelles are a promising carrier for delivery of anticancer drugs to enhance cancer treatment.