Association between psoriasis and vitamin D: Duration of disease correlates with decreased vitamin D serum levels. Issue 25 (June 2018)

• Record Type: Journal Article
• Authors: Filoni, Angela; Vestita, Michelangelo; Congedo, Maurizio; Giudice, Giuseppe; Tafuri, Silvio; Bonamonte, Domenico
• Other Names: Sinnberg. Tobias section editor.
• Is Part Of: Medicine. Volume 97:Issue 25(2018)
• Publication Date: 2018-06
• Subjects: association -- psoriasis -- psoriasis duration -- serum levels -- vitamin D; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000011185
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Recent literature has focused on the association of psoriasis with lower than normal or highly deficient vitamin D blood levels. To investigate the controversial association between psoriasis and vitamin D levels. From 2012 to 2014, 561 subjects were assessed, of which 170 had psoriasis, 51 had an autoimmune bullous, and 340 were healthy patients. Anagraphical data, 25(OH)D blood levels, and seasons of vitamin D levels assessments were recorded for each group. Vitamin D levels were significantly different among the 3 groups ( K = 151.284; P = .0001). Psoriatic patients had significantly lower serum levels of 25(OH)D (21.8 ng/mL) than healthy controls (34.3 ng/mL) (chi-square = 11.5; P = .0007). Patients with bullous diseases showed the lowest vitamin D mean values (18.2 ng/mL). The linear multiple regression model showed 25(OH)D levels to be influenced by age, season of blood vitamin D levels assessment, and psoriasis duration. These results confirm the reduced vitamin D levels in psoriatic patients when compared to healthy controls, and provide new evidence regarding the association of vitamin D levels and psoriasis duration. The limits of our study include its observational nature and the small number of patients undergoing biological immunosuppressive therapies.