A rare subtype of meningioma: Case series of anaplastic meningioma and review of the literature. Issue 23 (June 2018)

• Record Type: Journal Article
• Authors: Cao, Hongyi; Jiang, Biying; Zhao, Yang; Fan, Chuifeng
• Other Names: NA. section editor.
• Is Part Of: Medicine. Volume 97:Issue 23(2018)
• Publication Date: 2018-06
• Subjects: anaplastic meningioma -- case series -- meningioma; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000011019
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Anaplastic meningioma, a rare subtype of meningioma, has malignant morphological characteristics and a World Health Organization (WHO) grade of III. Patient concerns: In this report, we present findings from 6 cases of anaplastic meningioma. Diagnoses: Pathological examination of the tumors, including hematoxylin and eosin staining and immunohistochemical staining, was performed. Of the six cases of anaplastic meningioma, two were recurrent tumors from original seminoma with a WHO grade of I. Histologically, three cases had carcinoma-like morphology, one case had sarcoma-like morphology, and two had two kinds of tissue structures: carcinoma-like tumor cell nests and areas with spindle tumor cells. Necrosis was detected in most cases (5/6). Ki67 index was high and varied from 20% to 70%. Interventions: All the patients received surgery. 3 patients received adjuvant radiotherapy. 1 patient received chemotherapy. Outcomes: 4 patients had no recurrence at follow-up of 19, 30, 46 and 54 months after the last surgery. 1 patient had recurrence 3 months after the last surgery. 1 patient died 12 days after the last surgery. Lessons: This malignant subtype can be secondary to a WHO grade I meningioma after a long quiescent period. Necrosis was common in the tumor tissues, and Ki67 index was usually high. For patients with a history of meningioma, including benign cases, regular physical examination is important for early detection of tumor recurrence and malignant transformation.