Noninfectious Fever in the Near-Term Pregnant Rat Induces Fetal Brain Inflammation: A Model for the Consequences of Epidural-associated Maternal Fever. Issue 2 (June 2018)

• Record Type: Journal Article
• Authors: Segal, S.; Pancaro, C.; Bonney, I.; Marchand, J.E.
• Is Part Of: Obstetric anesthesia digest. Volume 38:Issue 2(2018)
• Publication Date: 2018-06
• Subjects: Anesthetic Complications -- Analgesia for Labor -- Neonatal Morbidity and Mortality; Anesthesia in obstetrics -- Periodicals; Anesthesia in obstetrics -- Abstracts -- Periodicals; 617.968205
• DOI: 10.1097/01.aoa.0000532250.93150.8c
• Languages: English
• ISSNs: 0275-665X

Abstract

Abstract : ( Anesth Analg . 2017;125(6):2134–2140) Intrapartum fever of noninfectious etiology during deliveries in women with labor epidural analgesia may adversely affect the developing fetal brain. A proinflammatory cytokine, interleukin (IL)-6, found to be present at increased levels in epidural-associated maternal fever, has been linked to neonatal brain injury. As there is no comprehensive animal model of labor epidural analgesia, the authors of the present study developed a model of noninfectious inflammatory fever in the near-term pregnant rat using IL-6 levels comparable to those found in human patients with labor epidural analgesia-associated fever. They hypothesized that brief administration of IL-6 would induce a core temperature increase in the dams and induce neuroinflammation in the fetus.