Migraine is related to an increased risk of Parkinson's disease: A population-based, propensity score-matched, longitudinal follow-up study. (December 2016)

• Record Type: Journal Article
• Authors: Wang, Hsin-I; Ho, Yu-Chun; Huang, Ya-Ping; Pan, Shin-Liang
• Is Part Of: Cephalalgia. Volume 36:Number 14(2016)
• Page Start: 1316
• Page End: 1323
• Publication Date: 2016-12
• Subjects: Migraine -- Parkinson's disease -- risk factors -- propensity score; Headache -- Periodicals; 616.8491
• DOI: 10.1177/0333102416630577
• Languages: English
• ISSNs: 0333-1024

Abstract

Background: The association between migraine and Parkinson's disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD. Methods: A total of 41, 019 subjects aged between 40 and 90 years with at least two ambulatory visits with a diagnosis of migraine in 2001 were enrolled in the migraine group. A logistic regression model that included age, sex, pre-existing comorbidities and socioeconomic status as covariates was used to compute the propensity score. The non-migraine group consisted of 41, 019 propensity score-matched, randomly sampled subjects without migraine. The PD-free survival rate were estimated using the Kaplan–Meier method. Stratified Cox proportional hazard regression was used to estimate the effect of migraine on the risk of developing PD. Results: During follow-up, 148 subjects in the migraine group and 101 in the non-migraine group developed PD. Compared to the non-migraine group, the hazard ratio of PD for the migraine group was 1.64 (95% confidence interval: 1.25–2.14, p = 0.0004). The PD-free survival rate for the migraine group was significantly lower than that for the non-migraine group ( p = 0.0041). Conclusions: This study showed an increased risk of developing PD in patients with migraine.