Bioavailable IGF-1 is beneficially associated with biomarkers of endothelial function in young healthy adults: The African-PREDICT study. (August 2018)

• Record Type: Journal Article
• Authors: Barnard, Sunelle A.; Smith, Wayne; Mels, Catharina M.C.; Botha, Shani; Schutte, Aletta E.
• Is Part Of: Growth hormone & IGF research. Volume 41(2018)
• Page Start: 28
• Page End: 33
• Publication Date: 2018-08
• Subjects: Vascular function -- Youth -- Age -- Endothelial activation -- Insulin-like growth factor-1 -- Insulin-like growth factor-binding protein-3 -- von Willebrand factor -- Intercellular adhesion molecule-1 -- Vascular cell adhesion molecule-1; ABPM ambulatory blood pressure monitoring -- African-PREDICT African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension -- BMI body mass index -- IGF-1 insulin-like growth factor-1 -- IGFBP-3 IGF binding protein-3 -- ICAM-1 intercellular adhesion molecule-1 -- SES socioeconomic status -- VCAM-1 vascular cell adhesion molecule-1 -- vWFag von Willebrand factor antigen; Growth regulators -- Periodicals; Growth -- Regulation -- Periodicals; Somatomedin -- Periodicals; Somatomedins -- Periodicals; Growth Hormone -- Periodicals; Growth Substances -- Periodicals; Croissance -- Régulation -- Périodiques; Croissance -- Régulateurs -- Périodiques; Somatotrophine -- Périodiques; Somatomédine -- Périodiques; Growth -- Regulation; Growth regulators; Electronic journals; Periodicals; Electronic journals; 612.4
• DOI: 10.1016/j.ghir.2018.06.002
• Languages: English
• ISSNs: 1096-6374

Abstract

Abstract: Introduction: Low circulating levels of insulin-like growth factor-1 (IGF-1) are associated with endothelial dysfunction, subsequently leading to the development of cardiovascular disease. Objective: To better understand the early phases of vascular deterioration in a young, healthy population, we investigated, cross-sectionally, whether biomarkers of endothelial function (intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and von Willebrand factor antigen (vWFag )) are associated with IGF-1 in a healthy study population forming part of the larger African Prospective study on the Early Detection and Identification of Cardiovascular diseases and Hypertension (African-PREDICT). Method: We included 825 black and white men and women (aged 20–30 years) and determined IGF-1, IGF binding protein-3 (IGFBP-3), ICAM-1, VCAM-1 and vWFag from blood samples. We also measured 24-h blood pressure and health behaviours namely waist circumference, accelerometery, cotinine and gamma glutamyl transferase. We used the IGF-1/IGFBP-3 M ratio as an estimate of bioavailable IGF-1. Results: In multivariable-adjusted regression analyses performed in the total group, VCAM-1 associated positively with IGFBP-3 (β = 0.21; p < .001) and negatively with IGF-1/IGFBP-3 (β = −0.18; p < .001). ICAM-1 showed a borderline negative association with IGF-1 (β = −0.09; p = .054) and IGF-1/IGFBP-3 (β = −0.08; p = .057). vWFag was not associated with IGF-1, IGFBP-3 or bioavailable IGF-1. Conclusion: VCAM-1 is beneficially associated with IGF-1 in a young healthy cohort, independent of sex, ethnicity, blood pressure and health behaviours – thereby confirming the potential importance of bioavailable IGF-1 in early vascular endothelial protection. Highlights: Role of IGF-1 in early phases of cardiovascular disease development unclear. In young adults we found IGF-1 linked inversely to endothelial activation. Our findings support the role of IGF-1 in early vascular endothelial protection.