Unraveling Interfaces between Energy Metabolism and Cell Cycle in Plants. (August 2018)

• Record Type: Journal Article
• Authors: Siqueira, João Antonio; Hardoim, Pablo; Ferreira, Paulo C.G.; Nunes-Nesi, Adriano; Hemerly, Adriana S.
• Is Part Of: Trends in plant science. Volume 23:Number 8(2018)
• Page Start: 731
• Page End: 747
• Publication Date: 2018-08
• Subjects: Cell division control -- energy fluctuations -- mitochondria -- chloroplast -- protein turnover; Botany -- Periodicals; Botanique -- Périodiques; Botany; Periodicals; 580.5
• DOI: 10.1016/j.tplants.2018.05.005
• Languages: English
• ISSNs: 1360-1385

Abstract

Abstract : Oscillation in energy levels is widely variable in dividing and differentiated cells. To synchronize cell proliferation and energy fluctuations, cell cycle-related proteins have been implicated in the regulation of mitochondrial energy-generating pathways in yeasts and animals. Plants have chloroplasts and mitochondria, coordinating the cell energy flow. Recent findings suggest an integrated regulation of these organelles and the nuclear cell cycle. Furthermore, reports indicate a set of interactions between the cell cycle and energy metabolism, coordinating the turnover of proteins in plants. Here, we discuss how cell cycle-related proteins directly interact with energy metabolism-related proteins to modulate energy homeostasis and cell cycle progression. We provide interfaces between cell cycle and energy metabolism-related proteins that could be explored to maximize plant yield. Highlights: In heterotrophic cells, there is a bidirectional connection between cell division and mitochondrial metabolism, in which cell cycle-related proteins control energy flux in the cytosol, dependent on the cell cycle phases. Metabolic oscillations play a crucial role in cell cycle regulation in yeasts. Specific mechanisms to sense cell energy status are apparently responsible for directing the different cell cycle phases. Similar features in plants suggest the importance of these metabolic controls for cell cycle modulation. Photoautotrophic plant cells, with their energy-converting chloroplasts, may present unique characteristics for cell cycle regulation, dependent on chloroplastidial and mitochondrial energy cues. The understanding of regulatory modules coordinating cell cycle and energy metabolism could be instrumental for increasing plant yield.