Changes of meibomian glands in the early stage of post hematopoietic stem cell transplantation. (October 2017)

• Record Type: Journal Article
• Authors: Kim, Seonjoo; Yoo, Young-Sik; Kim, Hyun Seung; Joo, Choun-Ki; Na, Kyung-Sun
• Is Part Of: Experimental eye research. Volume 163(2017)
• Page Start: 85
• Page End: 90
• Publication Date: 2017-10
• Subjects: Hematopoietic stem cell transplantation -- Meibomian glands -- Graft-versus-host disease; Ophthalmology -- Periodicals; Eye -- Periodicals; Œil -- Périodiques; Ophthalmology; Periodicals; Electronic journals; 612.8405
• DOI: 10.1016/j.exer.2017.07.013
• Languages: English
• ISSNs: 0014-4835

Abstract

Abstract: Hematopoietic stem cell transplantation (HSCT) is the most effective cure for hematologic malignancies. Graft-versus-host disease (GVHD) is a major complication following allogeneic HSCT, which significantly affects non-relapse mortality. And ocular manifestations of GVHD are known to occurin 60–90% of patients with chronic GVHD. Although the pathogenesis of ocular GVHD is not clearly known, it is known to progress into inflammation and fibrosis through presentation of antigens on CD4 and CD8 T cells. There is much evidence that the ocular surface and meibomian glands are severely damaged in ocular GVHD patients, and there are few observational studies on the early changes. In this review, we will discuss the various changes in the meibomian glands and ocular surface, and tear dynamics in the early stage following HSCT. These results show that tear film break-up time (TFBUT) decreased and the corneal staining score was significantly higher 2–3 months after HSCT. The upper eyelid and total eyelid meiboscore increased after 3 months following HSCT. The information of the early changes of meibomian glands morphology would be helpful to further examine the pathogenesis of meibomian gland dysfunction. Highlights: The ocular surface and meibomian glands were severely damaged in ocular graft-versus-host disease patients. The changes of the ocular surface may have started in the early stage following hematopoietic stem cell transplantation. The meibomian glands varied greatly, which showed rapid loss, or revisualizing of lost ducts in the early stage of HSCT.