Impaired glucose metabolism is associated with tooth loss in middle-aged adults: The Northern Finland Birth Cohort Study 1966. (August 2018)

• Record Type: Journal Article
• Authors: Similä, Toni; Auvinen, Juha; Puukka, Katri; Keinänen-Kiukaanniemi, Sirkka; Virtanen, Jorma I.
• Is Part Of: Diabetes research and clinical practice. Volume 142(2018)
• Page Start: 110
• Page End: 119
• Publication Date: 2018-08
• Subjects: Prediabetes -- Impaired fasting glucose -- Impaired glucose tolerance -- Tooth loss -- Adult; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2018.05.035
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: Tooth loss associates with impaired glucose metabolism in middle-aged adults. Even prediabetic glucose metabolism associates with tooth loss in middle-aged adults. Tooth loss could be used as a simple indicator of impaired glucose metabolism. Abstract: Aim: We investigated the association of impaired glucose metabolism with tooth loss in adults in the Northern Finland Birth Cohort Study 1966 (NFBC1966). Methods: We examined 4394 participants from the 46-year follow-up of the NFBC1966. Self-reported number of teeth as well as insulin and glucose values, taken during a standard oral glucose tolerance test (OGTT), served as the primary study variables. A multinomial logistic regression model served to analyse (unadjusted, smoking-adjusted and fully adjusted) the association between number of teeth (0–24, 25–27, 28–32) and glucose metabolism in women and men. Results: Among women, type 2 diabetes – whether previously known or detected during screening – pointed to a higher likelihood of 0–24 teeth (fully adjusted OR = 2.99, 95%CI = 1.54–5.80) and 25–27 teeth (OR = 1.91, 95%CI = 1.18–3.08) than did normal glucose tolerance. Similarly, impaired fasting glucose and impaired glucose tolerance together indicated a higher likelihood of 0–24 teeth (OR = 1.71, 95%CI = 1.09–2.69) than did normal glucose tolerance. A similar, statistically non-significant, pattern emerged among men. Number of teeth associated with OGTT insulin and glucose curves as well as with the Matsuda index in both women and men. Conclusions: Tooth loss strongly associated with impaired glucose metabolism in middle-aged Finnish women.