Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis. (2nd October 2015)

• Record Type: Journal Article
• Authors: Russo, Giorgio Ivan; Castelli, Tommaso; Urzì, Daniele; Privitera, Salvatore; Fragalà, Eugenia; La Vignera, Sandro; Condorelli, Rosita A.; Calogero, Aldo E.; Favilla, Vincenzo; Cimino, Sebastiano; Morgia, Giuseppe
• Is Part Of: Aging male. Volume 18:Number 4(2015:Dec.)
• Page Start: 207
• Page End: 216
• Publication Date: 2015-10-02
• Subjects: Age -- benign prostatic enlargement -- insulin resistance -- LUTS -- metabolic syndrome -- non-alcholic fatty liver disease -- prostate -- testosterone; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.3109/13685538.2015.1062980
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: A significant amount of epidemiological evidences have underlined an emerging link between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement a (BPE). We aimed to assess the connections between LUTS and MetS with its components. Meta-analysis were conducted to determine the mean differences (MD) and confidence intervals of IPSS total score, IPSS-voiding, IPSS-storage and prostate volume (PV) in patients with or without MetS. Ln(odds-ratio) were calculated to estimate the risk of having moderate-to-severe LUTS (IPSS ≥ 8). Nineteen studies were identified as eligible for this systematic review, with a total of 18, 476 participants, including 5554 (30.06%) with and 12 922 (69.94%) without MetS. Pooled analysis did not demonstrate significant MD of IPSS, IPSS-voiding and IPSS-storage in men with or without MetS but PV was significantly different (MD = 2.18; p = 0.03). Presence of MetS was not significantly associated with moderate-to-severe LUTS (odds ratio = 1.13; p = 0.53) and only altered serum triglycerides and diabetes were associated with this risk. The association between MetS and LUTS/BPE remain unclear and further observational studies in a population with metabolic disorders should be conducted in order to address it's potential role in determining LUTS/BPE.