Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines12. Issue 59 (5th July 2018)

• Record Type: Journal Article
• Authors: Bao, Wen; Wang, Jun-Qi; Xu, Xue-Tao; Zhang, Bang-Hong; Liu, Wei-Ting; Lei, Lin-Sheng; Liang, Huan; Zhang, Kun; Wang, Shao-Hua
• Is Part Of: Chemical communications. Volume 54:Issue 59(2018)
• Page Start: 8194
• Page End: 8197
• Publication Date: 2018-07-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc04733b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient strategy for the synthesis of substituted 1-aminoisoquinoline has been developed. Abstract : A Cu(acac)2 -catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates has been successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinolines. The reaction proceeds smoothly under mild conditions with high efficiency, and might provide an alternative strategy for the synthesis of 1-aminoisoquinoline containing molecules.