Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba4Yb3F17:Lu3+, Gd3+  1. Issue 28 (4th July 2018)

• Record Type: Journal Article
• Authors: Ma, Sihan; Zhang, Jiaxin; Xia, Shibo; Yin, Wenyan; Qin, Yanxia; Lei, Runhong; Kong, Jianglong; Mei, Linqiang; Li, Juan; Xin, Gengmei; Li, Gongping
• Is Part Of: Nanoscale. Volume 10:Issue 28(2018)
• Page Start: 13402
• Page End: 13409
• Publication Date: 2018-07-04
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c8nr03054e
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Designing nanosized multi-modality contrast agents for high-resolution imaging is challenging since most agents are only useful for single-mode imaging. Abstract : Designing nanosized multi-modality contrast agents for high-resolution imaging is challenging since most agents are only useful for single-mode imaging. In this work, we successfully synthesized biocompatible polyethylene glycol (PEG-) andl -glutamine (GLN-) modified Ba4 Yb3 F17 :Lu 3+, Gd 3+ nanoparticles (LNPs@PEG@GLN) that can be employed as a multi-modality contrast agent. Fluorescence dye-modified LNPs@PEG@GLN nanoparticles can be used for computed tomography (CT), magnetic resonance imaging (MRI), and fluorescence imaging (FI). They display high X-ray absorption, outstanding T 2 -weighted imaging capability, and good fluorescence uptake. Furthermore, LNPs@PEG@GLN enhances contrast efficiencies for different imaging modalities in vivo . Interestingly, LNPs@PEG@GLN is a promising agent for CT angiography. These nanoparticles could be a promising contrast agent for multi-modality imaging and diagnosing vascular diseases.