Palladium-catalyzed direct C(sp3)–H arylation of indole-3-ones with aryl halides: a novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones. Issue 45 (16th July 2018)

• Record Type: Journal Article
• Authors: Zhao, Yong-Long; Tang, Yong-Qin; Fei, Xing-Hai; Xiao, Tao; Lu, Ya-Dong; Fu, Xiao-Zhong; He, Bin; Zhou, Meng; Li, Chun; Xu, Peng-Fei; Yang, Yuan-Yong
• Is Part Of: RSC advances. Volume 8:Issue 45(2018)
• Page Start: 25292
• Page End: 25297
• Publication Date: 2018-07-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra04807j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones via palladium-catalyzed direct C(sp 3 )–H arylation of indole-3-ones with aryl halides has been developed. Abstract : A novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones via palladium-catalyzed direct C(sp 3 )–H arylation of indole-3-ones with aryl halides has been developed. Various 2-monoarylated indole-3-ones were readily obtained with yields up to 95%. As a class of important nucleophilic intermediates, 2-monoarylated indole-3-ones can be used for the construction of C2-quaternary indolin-3-one skeletons.