40 YEARS OF IGF1: PAPP-A and cancer. (July 2018)

• Record Type: Journal Article
• Authors: Conover, Cheryl A; Oxvig, Claus
• Is Part Of: Journal of molecular endocrinology. Volume 61:Number 1(2018)
• Page Start: T1
• Page End: T10
• Publication Date: 2018-07
• Subjects: pregnancy-associated plasma protein-A -- insulin-like growth factor -- stanniocalcin -- breast cancer -- ovarian cancer -- lung cancer -- mesothelioma -- melanoma -- Ewing sarcoma; Molecular endocrinology -- Periodicals; Endocrinology -- Periodicals; 616.407
• DOI: 10.1530/JME-17-0236
• Languages: English
• ISSNs: 0952-5041

Abstract

Abstract : The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.