Illuminating GPCR Signaling by Cryo-EM. Issue 8 (August 2018)

• Record Type: Journal Article
• Authors: Safdari, Haaris Ahsan; Pandey, Shubhi; Shukla, Arun K.; Dutta, Somnath
• Is Part Of: Trends in cell biology. Volume 28:Issue 8(2018)
• Page Start: 591
• Page End: 594
• Publication Date: 2018-08
• Subjects: GPCR -- cryo-EM -- biased signaling -- arrestins -- negative-staining; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2018.06.002
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : The wave of resolution revolution in cryo-EM has touched, and made a significant impact on, the structural biology of GPCRs. High-resolution structures of several GPCR-G-protein complexes are now determined by cryo-EM and they illuminate fine structural details of this central macromolecular complex involved in cellular signaling.