Utility of pyrosequencing for rapid detection of tubercular meningitis (TBM) and associated susceptibility directly from CSF specimens. (July 2018)

• Record Type: Journal Article
• Authors: Ajbani, Kanchan; Kazi, Mubin; Naik, Swapna; Soman, Rajeev; Shetty, Anjali; Rodrigues, Camilla
• Is Part Of: Tuberculosis. Volume 111(2018)
• Page Start: 54
• Page End: 56
• Publication Date: 2018-07
• Subjects: 616.995
• DOI: 10.1016/j.tube.2018.05.009
• Languages: English
• ISSNs: 1472-9792

Abstract

Abstract: Tubercular meningitis (TBM) is a serious form of tuberculosis (TB). The diagnosis of TBM & susceptibility/resistance is difficult as TB MGIT culture lacks sensitivity & timeliness. Timely and accurate diagnosis of the TBM is the need of the hour for initiation of appropriate therapy. We have exploited pyrosequencing to detect TB and associated Multi/extensively drug resistant (MDR/ XDR-TB) directly from Cerebrospinal Fluid (CSF) specimens.