Histopathological and Immunohistochemical Study of Trichoblastoma in the Rabbit. Issue 2 (August 2017)

• Record Type: Journal Article
• Authors: Kok, M.K.; Chambers, J.K.; Ushio, N.; Watamori, A.; Miwa, Y.; Nakayama, H.; Uchida, K.
• Is Part Of: Journal of comparative pathology. Volume 157:Issue 2/3(2017)
• Page Start: 126
• Page End: 135
• Publication Date: 2017-08
• Subjects: immunohistochemistry -- papillary mesenchymal bodies -- rabbit -- trichoblastoma; Veterinary pathology -- Periodicals; Veterinary therapeutics -- Periodicals; Pathology, Comparative -- Periodicals; Therapeutics -- Periodicals; Pathology, Veterinary -- Periodicals; 636.089607
• DOI: 10.1016/j.jcpa.2017.06.005
• Languages: English
• ISSNs: 0021-9975

Abstract

Summary: Trichoblastoma is the most common skin tumour in the rabbit. The aim of the present study was to characterize the histological and immunohistochemical features of trichoblastoma in 27 rabbits. Common sites of tumour occurrence were the neck (6/30, 20%), head (5/30, 16.7%), flank (4/30, 13.3%) and hindlimb (4/30, 13.3%). Histologically, rabbit trichoblastoma was categorized into ribbon (10/30, 33.3%), trabecular (8/30, 26.7%) and mixed types (12/30, 40%). The tumour tissue showed close interaction with the surrounding stroma where prominent fibroblastic aggregation, known as papillary mesenchymal bodies, was frequently observed (24/30; 80%). Peritumoural stroma of all cases was stained by Alcian blue (at pH 2.5 with weaker staining at pH 1.0). Immunohistochemically, the peripheral palisading basal-type cells of the tumour were positive for cytokeratin (CK) 14 while the inner cells were typically positive for CK17, differing from the immunohistochemical profile of the rabbit epidermis and hair follicle. The present study suggests that uncontrolled embryonic trichogenesis is involved in the development of trichoblastoma in the rabbit.