A new computational intelligence approach to detect autistic features for autism screening. (September 2018)

• Record Type: Journal Article
• Authors: Thabtah, Fadi; Kamalov, Firuz; Rajab, Khairan
• Is Part Of: International journal of medical informatics. Volume 117(2018)
• Page Start: 112
• Page End: 124
• Publication Date: 2018-09
• Subjects: Accuracy -- Autism Spectrum Disorder -- Behaviour science -- Classifiers -- Computational intelligence -- Data mining -- Feature analysis -- Machine learning -- Sensitivity -- Specificity; Medical informatics -- Periodicals; Information science -- Periodicals; Computers -- Periodicals; Medical technology -- Periodicals; Medical Informatics -- Periodicals; Technology, Medical -- Periodicals; Computers; Information science; Medical informatics; Medical technology; Electronic journals; Periodicals; Electronic journals; 610.285
• DOI: 10.1016/j.ijmedinf.2018.06.009
• Languages: English
• ISSNs: 1386-5056

Abstract

Highlights: New feature selection method based on simplified likelihoods of observed and predicted values of variables is proposed. Reduction of the features space and sustaining performance based on large numbers of experimentations. Detecting new effective autistic traits related to autism screening using machine learning. Maintaining performance in terms of predictive accuracy, sensitivity, and specificity rates using real behavioral datasets. Abstract: Autism Spectrum Disorder (ASD) is one of the fastest growing developmental disability diagnosis. General practitioners (GPs) and family physicians are typically the first point of contact for patients or family members concerned with ASD traits observed in themselves or their family member. Unfortunately, some families and adult patients are unaware of ASD traits that may be exhibited and as a result do not seek out necessary diagnostic services or contact their GP. Therefore, providing a quick, accessible, and simple tool utilizing items related to ASD to these families may increase the likelihood they will seek professional assessment and is vital to the early detection and treatment of ASD. This study aims at identifying fewer, albeit influential, features in common ASD screening methods in order to achieve efficient screening as demands on evaluating the items' influences on ASD within existing tools is urgent. To achieve this aim, a computational intelligence method called Variable Analysis (Va) is proposed that considers feature-to-class correlations and reduces feature-to-feature correlations. The results of the Va have been verified using two machine learning algorithms by deriving automated classification systems with respect to specificity, sensitivity, positive predictive values (PPVs), negative predictive values (NPVs), and predictive accuracy. Experimental results using cases and controls related to items in three common screening methods, along with features related to individuals, have been analysed and compared with results obtained from other common filtering methods. The results exhibited that Va was able to derive fewer numbers of features from adult, adolescent, and child screening methods yet maintained competitive predictive accuracy, sensitivity, and specificity rates.