Characterization of reward and effort mechanisms in apathy. Issue 1 (February 2015)

• Record Type: Journal Article
• Authors: Bonnelle, Valerie; Veromann, Kai-Riin; Burnett Heyes, Stephanie; Lo Sterzo, Elena; Manohar, Sanjay; Husain, Masud
• Is Part Of: Journal of physiology -Paris. Volume 109:Issue 1/3(2015)
• Page Start: 16
• Page End: 26
• Publication Date: 2015-02
• Subjects: LARS-e Lille Apathy Rating Scale – extended version -- AI Action Initiation -- ER Emotional Responsiveness -- IC Intellectual Curiosity -- SA Self-Awareness -- DASS Depression, Anxiety, Stress Scales -- SHAPS Snaith–Hamilton Pleasure Scale -- MVC Maximum Voluntary Contraction -- IP Indifference Point -- IL Indifference Line -- AIC Akaike Information Criteria -- PD Parkinson's disease; Motivation -- Decision-making -- Action Initiation -- Effort discounting -- Apathy; Physiology -- Periodicals; 571.105
• DOI: 10.1016/j.jphysparis.2014.04.002
• Languages: English
• ISSNs: 0928-4257

Abstract

Highlights: Apathy in the normal population is dissociable from depression and anhedonia. Apathy in the normal population is related to the modulation of physical effort people are willing to engage. Apathy in the normal population is associated with higher subjective effort costs for small rewards. Abstract: Apathy is a common but poorly understood condition with a wide societal impact observed in several brain disorders as well as, to some extent, in the normal population. Hence the need for better characterization of the underlying mechanisms. The processes by which individuals decide to attribute physical effort to obtain rewards might be particularly relevant to relate to apathy traits. Here, we designed two paradigms to assess individual differences in physical effort production and effort-based decision-making and their relation to apathy in healthy people. Apathy scores were measured using a modified version of the Lille Apathy Rating Scale, suitable for use in a non-clinical population. In the first study, apathy scores were correlated with the degree to which stake (reward on offer) and difficulty level impacts on physical effort production. Individuals with relatively high apathy traits showed an increased modulation of effort while more motivated individuals generally exerted greater force across different levels of stake. To clarify the underlying mechanisms for this behavior, we designed a second task that allows independent titration of stake and effort levels for which subjects are willing to engage in an effortful response to obtain a reward. Our results suggest that apathy traits in the normal population are related to the way reward subjectively affects the estimation of effort costs, and more particularly manifest as decreased willingness to exert effort when rewards are small, or below threshold. The tasks we introduce here may provide useful tools to further investigate apathy in clinical populations.