One-pot, three-component synthesis of spiro[indeno[1, 2-b]quinoline-10, 3′-pyrroles] via the Hantzsch-type reaction of 1H-pyrrole-2, 3-diones. Issue 1 (4th January 2017)

• Record Type: Journal Article
• Authors: Dmitriev, Maksim V.; Salnikova, Tatyana V.; Silaichev, Pavel S.; Maslivets, Andrey N.
• Is Part Of: Tetrahedron letters. Volume 58:Issue 1(2017)
• Page Start: 67
• Page End: 70
• Publication Date: 2017-01-04
• Subjects: Pyrroledione -- Indenoquinoline -- Multicomponent reaction -- Aminocyclohexenone -- Indanedione; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.11.100
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Efficient synthesis of spiro[indeno[1, 2- b ]quinoline-10, 3′-pyrroles]. The method is simple, metal-free and does not require column chromatography. Pyrrole-2, 3-diones were utilized for the first time using the Hantzsch-type reaction. Abstract: A new methodology for the synthesis of spiro[indeno[1, 2- b ]quinoline-10, 3′-pyrrole] derivatives via a Hantzsch-type reaction has been developed. This process involves the one-pot, three-component reaction of a 1 H -pyrrole-2, 3-dione, an aminocyclohexenone and 1, 3-indanedione in acetic acid at reflux. Operationally simple, metal-free reaction conditions, simplicity of product isolation and good yields are key advantages of this methodology.