Discovery of Hypocretin/Orexin Ushers in a New Era of Sleep Research. Issue 2 (February 2018)

• Record Type: Journal Article
• Authors: Prober, David A.
• Is Part Of: Trends in neurosciences. Volume 41:Issue 2(2018)
• Page Start: 70
• Page End: 72
• Publication Date: 2018-02
• Subjects: sleep -- arousal -- hypocretin -- orexin; Neurology -- Periodicals; Neurophysiology -- Periodicals; Neurobiology -- Periodicals; 612.8
• DOI: 10.1016/j.tins.2017.11.007
• Languages: English
• ISSNs: 0166-2236

Abstract

Abstract : Prior to the 21st century, genetic mechanisms that regulate sleep were largely unknown. In 1998, de Lecea et al . and Sakurai et al . reported the discovery of a gene they named hypocretin and orexin, respectively, which led to a revolution in our understanding of genetic and neuronal mechanisms that regulate sleep.