Vitamin D and cardiovascular disease. (September 2018)

• Record Type: Journal Article
• Authors: Apostolakis, Michail; Armeni, Eleni; Bakas, Panagiotis; Lambrinoudaki, Irene
• Is Part Of: Maturitas. Volume 115(2018)
• Page Start: 1
• Page End: 22
• Publication Date: 2018-09
• Subjects: VDR vitamin D receptor -- 25OHVitD 25-hydroxyvitamin D -- 1, 25(OH)2D3 1, 25-dihydroxyvitamin D3 -- PTH parathyroid hormone -- FMD flow-mediated dilation -- NFκB nuclear factor κB -- MESA Multi Ethnic Study of Atherosclerosis -- IMT intima media thickness -- ba-PWV brachial-ankle pulse wave velocity -- CAC coronary artery calcification -- PAD peripheral artery disease -- MrOS Osteoporotic Fractures in Men -- CHD coronary heart disease -- VDBP vitamin D binding protein -- ARIC Atherosclerosis Risk In Communities -- RECORD Randomized Evaluation of Calcium Or Vitamin D trial -- VITAL VITamin D and OmegA-3 Trial; Vitamin D supplementation -- Cardiovascular disease -- Coronary heart disease -- Hypertension -- Stroke -- Heart failure; Climacteric -- Periodicals; Menopause -- Periodicals; Climacteric -- Periodicals; Geriatrics -- Periodicals; Menopause -- Periodicals; Middle Aged -- Periodicals; Climatère -- Périodiques; Ménopause -- Périodiques; Climacterium; Climacteric; Menopause; Electronic journals; Periodicals; 612.66
• DOI: 10.1016/j.maturitas.2018.05.010
• Languages: English
• ISSNs: 0378-5122

Abstract

Highlights: Vitamin D is involved in cardiovascular physiology. Vitamin D deficiency is associated with increased subclinical and overt cardiovascular disease. It is still unclear whether vitamin D supplementation has a beneficial effect on cardiovascular outcomes. Patient characteristics, vitamin D status, dose/mode/duration of supplementation modulate the effect of vitamin D on CVD. Abstract: Vitamin D, a soluble steroid hormone synthesized in the skin after sun exposure, plays a crucial role in calcium metabolism and is also involved in cardiovascular pathophysiology. The aim of this review is to summarize the available evidence (a) on the association between endogenous vitamin D status and cardiovascular disease, and (b) on the effect of vitamin D supplementation on cardiovascular outcomes. Most studies have shown an inverse association between vitamin D levels and cardiovascular outcomes. Randomized controlled trials, however, do not consistently support a beneficial effect of vitamin D administration on cardiovascular health. Population characteristics, comorbid conditions such as diabetes, the overall population prevalence of cardiovascular disease, vitamin D status and the regimen of vitamin D supplementation may account for the conflicting results.