Radir package: an R implementation for cytogenetic biodosimetry dose estimation. (10th July 2015)

• Record Type: Journal Article
• Authors: Moriña, David; Higueras, Manuel; Puig, Pedro; Ainsbury, Elizabeth A; Rothkamm, Kai
• Is Part Of: Journal of radiological protection. Volume 35:Number 3(2015:Sep.)
• Page Start: 557
• Page End: 569
• Publication Date: 2015-07-10
• Subjects: cytogenetic dosimetry -- Bayesian methods -- inverse regression -- R software -- radir package -- radiation -- dose estimation; Radiation -- Safety measures -- Periodicals; Health Physics -- Periodicals; Radiation Monitoring -- Periodicals; Radiation Protection -- Periodicals; Rayonnement -- Sécurité -- Mesures -- Périodiques; Electronic journals; Fulltext; Internet Resource; Periodical; 363.179905
• DOI: 10.1088/0952-4746/35/3/557
• Languages: English
• ISSNs: 0952-4746

Abstract

Abstract: The Bayesian framework has been shown to be very useful in cytogenetic dose estimation. This approach allows description of the probability of an event in terms of previous knowledge, e.g. its expectation and/or its uncertainty. A newR package entitledradir (rad iationi nverser egression) has been implemented with the aim of reproducing a recent Bayesian-type dose estimation methodology.radir adopts the method of dose estimation under the Poisson assumption of the responses (the chromosomal aberrations counts) for the required dose-response curve (typically linear or quadratic). The individual commands are described in detail and relevant examples of the use of the methods and the correspondingradir software tools are given. The suitability of this methodology is highlighted and its application encouraged by providing a user-friendly command-type software interface within theR statistical software (version 3.1.1 or higher), which includes a complete manual.