The role of CKIP-1 in osteoporosis development and treatment. Issue 2 (February 2018)

• Record Type: Journal Article
• Authors: Peng, X.; Wu, X.; Zhang, J.; Zhang, G.; Li, G.; Pan, X.
• Is Part Of: Bone & joint research. Volume 7:Issue 2(2018)
• Page Start: 173
• Page End: 178
• Publication Date: 2018-02
• Subjects: Osteoporosis -- CKIP-1 -- Bone formation -- BMP pathway; Musculoskeletal system -- Periodicals; 573.705
• DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1
• Languages: English
• ISSNs: 2046-3758

Abstract

Abstract : Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. Cite this article : X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. Bone Joint Res 2018;7:173–178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1.