Protein Delivery: Bioinspired Diselenide‐Bridged Mesoporous Silica Nanoparticles for Dual‐Responsive Protein Delivery (Adv. Mater. 29/2018). Issue 29 (16th July 2018)

• Record Type: Journal Article
• Authors: Shao, Dan; Li, Mingqiang; Wang, Zheng; Zheng, Xiao; Lao, Yeh‐Hsing; Chang, Zhimin; Zhang, Fan; Lu, Mengmeng; Yue, Juan; Hu, Hanze; Yan, Huize; Chen, Li; Dong, Wen‐fei; Leong, Kam W.
• Is Part Of: Advanced materials. Volume 30:Issue 29(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-07-16
• Subjects: biodegradable mesoporous silica nanoparticles -- cancer‐cell‐membrane cloaking -- diselenide -- dual‐responsive -- protein delivery; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201870209
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : In article number1801198, Wen‐fei Dong, Kam W. Leong, and co‐workers report the development of an efficient protein‐delivery system comprising new biodegradable diselenide‐bridged mesoporous silica nanoparticles (MSNs) cloaked with cancer‐cell‐derived membrane fragments. The MSNs show oxidative and redox dual‐responsive matrix‐degradation behavior for controlled release of RNase A. They also exhibit prolonged blood circulation, favorable tumor accumulation, and low toxicity.