Back Cover: Bioactive Alkaloids from Indole‐3‐carbinol Exposed Culture of Daldiniaeschscholzii (Chin. J. Chem. 8/2018). Issue 8 (13th July 2018)

• Record Type: Journal Article
• Authors: Lin, Li Ping; Tan, Ren Xiang
• Is Part Of: Chinese journal of chemistry. Volume 36:Issue 8(2018)
• Page Start: 780
• Page End: 780
• Publication Date: 2018-07-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201880085
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract : The back cover picture shows Two new and rare bioactive indoles named dalesindoloids A (1 ) and B (3 ), along with 3‐(1 H ‐indole‐3ylmethyl)‐2‐oxindole (2 ), were characterized from the indole‐3‐carbinol (I3C)‐exposed culture of Daldinia eschscholzii . Dalesindoloids A and B were cytotoxic against the leukemia HL‐60 cell line with the IC50 values of 1.0 and 7.4 mol/L, respectively, with the former being inhibitory on Staphylococcus aureus (MIC: 9.1 μmol/L). The simultaneous characterization of the alkaloids from the I3C‐exposed fungal culture highlighted that the 2, 3‐epoxyindoline motif can be transformed into both lactam and indolin‐3‐one moieties. This is the first‐time description of the 2, 3‐epoxyindoline chemical versatility and Wagner‐Meerwein rearrangement (WMR) reaction in the microbial culture. More details are discussed in the article by Tan et al. on page 749–753. Abstract : The back cover picture shows Two new and rare bioactive indoles named dalesindoloids A (1 ) and B (3 ), along with 3‐(1 H ‐indole‐3ylmethyl)‐2‐oxindole (2 ), were characterized from the indole‐3‐carbinol (I3C)‐exposed culture of Daldinia eschscholzii . Dalesindoloids A and B were cytotoxic against the leukemia HL‐60 cell line with the IC50 values of 1.0 and 7.4 mol/L, respectively, with the former being inhibitory on Staphylococcus aureus (MIC: 9.1 μmol/L). The simultaneous characterization of the alkaloids from the I3C‐exposed fungal culture highlighted that the 2, 3‐epoxyindoline motif can be transformed into both lactam and indolin‐3‐one moieties. This is the first‐time description of the 2, 3‐epoxyindoline chemical versatility and Wagner‐Meerwein rearrangement (WMR) reaction in the microbial culture. More details are discussed in the article by Tan et al. on page 749–753.