Programmed Nanoparticle‐Loaded Nanoparticles for Deep‐Penetrating 3D Cancer Therapy. Issue 29 (18th May 2018)

• Record Type: Journal Article
• Authors: Kim, Jinhwan; Jo, Changshin; Lim, Won‐Gwang; Jung, Sungjin; Lee, Yeong Mi; Lim, Jun; Lee, Haeshin; Lee, Jinwoo; Kim, Won Jong
• Is Part Of: Advanced materials. Volume 30:Issue 29(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-05-18
• Subjects: deep penetration -- DNA engineering -- gold nanoparticle -- large‐pored mesoporous silica nanoparticle -- tumor pH gradient; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201707557
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Tumors are 3D, composed of cellular agglomerations and blood vessels. Therapies involving nanoparticles utilize specific accumulations due to the leaky vascular structures. However, systemically injected nanoparticles are mostly uptaken by cells located on the surfaces of cancer tissues, lacking deep penetration into the core cancer regions. Herein, an unprecedented strategy, described as injecting "nanoparticle‐loaded nanoparticles" to address the long‐lasting problem is reported for effective surface‐to‐core drug delivery in entire 3D tumors. The "nanoparticle‐loaded nanoparticle" is a silica nanoparticle (≈150 nm) with well‐developed, interconnected channels (diameter of ≈30 nm), in which small gold nanoparticles (AuNPs) (≈15 nm) with programmable DNA are located. The nanoparticle (AuNPs)‐loaded nanoparticles (silica): (1) can accumulate in tumors through leaky vascular structures by protecting the inner therapeutic AuNPs during blood circulation, and then (2) allow diffusion of the AuNPs for penetration into the entire surface‐to‐core tumor tissues, and finally (3) release a drug triggered by cancer‐characteristic pH gradients. The hierarchical "nanoparticle‐loaded nanoparticle" can be a rational design for cancer therapies because the outer large nanoparticles are effective in blood circulation and in protection of the therapeutic nanoparticles inside, allowing the loaded small nanoparticles to penetrate deeply into 3D tumors with anticancer drugs. Abstract : Programmed nanoparticle‐loaded nanoparticles, comprising large‐pored silica nanoparticles and DNA‐modified gold nanoparticles, exhibit sequential dynamic behavior for cancer therapy with three stages operated by DNA transition: preferential accumulation in the cancerous region, deep penetration into the 3D cancer tissues, and intracellular specific anticancer drug release.