Branched Fatty Acyl Esters of Hydroxyl Fatty Acids (FAHFAs), Appealing Beneficial Endogenous Fat against Obesity and Type‐2 Diabetes. Issue 38 (20th June 2018)

• Record Type: Journal Article
• Authors: Balas, Laurence; Feillet‐Coudray, Christine; Durand, Thierry
• Is Part Of: Chemistry. Volume 24:Issue 38(2018)
• Page Start: 9463
• Page End: 9476
• Publication Date: 2018-06-20
• Subjects: diabetes -- fatty acids -- insulin resistance -- saturated lipids -- synthetic methods; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201800853
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: After a brief overview of the biological significance of FAHFAs, the present Minireview highlights the different strategies developed for their chemical syntheses. The term "FAHFAs" has been introduced in 2014 for fatty acyl esters of hydroxyl fatty acids, found in adipocytes, with antidiabetic properties. However, many other natural products contain this type of branched lipids in their structure. This review was then extended to the synthesis of these subunits, even though the length of the lipid chains and the location of the ester linkages are different, since the developed strategies may be applied to the synthesis of "FAHFA". Abstract : Branching out : This Minireview discusses branched fatty acyl esters of hydroxyl fatty acids (FAHFAs), including their biological significance, different strategies developed for their chemical syntheses as well as the synthesis of other natural products that contain this type of branched lipids in their structure.