Serum uric acid to creatinine ratio correlates with β‐cell function in type 2 diabetes. Issue 5 (22nd May 2018)

• Record Type: Journal Article
• Authors: Li, Minchao; Gu, Liubao; Yang, Jun; Lou, Qinglin
• Is Part Of: Diabetes/metabolism research and reviews. Volume 34:Issue 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-05-22
• Subjects: serum uric acid -- SUA to creatinine ratio -- type 2 diabetes mellitus -- β‐cell function; Diabetes -- Periodicals; Metabolism -- Periodicals; 616.642
• DOI: 10.1002/dmrr.3001
• Languages: English
• ISSNs: 1520-7552

Abstract

Abstract: Background: The correlation between serum uric acid (SUA) and β‐cell function remains controversial. The present study aims to use a new index, renal function‐normalized SUA, to observe its correlation with β‐cell function in patients with type 2 diabetes (T2DM). Methods: A total of 713 patients with T2DM received standard 75‐g oral glucose tolerance and insulin release test. Renal function‐normalized SUA was calculated using SUA/creatinine and β‐cell function was assessed by HOMA‐B. Binary logistic regression analysis was used to estimate the association between SUA/creatinine and β‐cell function. Results: There are positive correlations between SUA/creatinine and HOMA‐B ( r = 0.143, P < 0.001), as well as other indexes of β‐cell function including modified β‐cell function index ( r = 0.104, P = 0.007), InsAUC30 ( r = 0.100, P = 0.008), and InsAUC120 ( r = 0.124, P = 0.001). SUA/creatinine also positively correlates with insulin resistance (HOMA‐IR: r = 0.161, P < 0.001). Moreover, multivariate analysis revealed that SUA/creatinine was significantly associated with preserved β‐cell function, independently of potential confounders including sex, BMI, and renal function. Conclusions: SUA to creatinine ratio correlates with β‐cell function in T2DM patients.