Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin‐Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration. Issue 12 (25th March 2018)

• Record Type: Journal Article
• Authors: Karimi, Fatemeh; O'Connor, Andrea J.; Qiao, Greg G.; Heath, Daniel E.
• Is Part Of: Advanced healthcare materials. Volume 7:Issue 12(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-25
• Subjects: biomaterials -- cell signaling -- focal adhesion -- multivalent ligands -- nanopatterning; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201701324
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Material systems that exhibit tailored interactions with cells are a cornerstone of biomaterial and tissue engineering technologies. One method of achieving these tailored interactions is to biofunctionalize materials with peptide ligands that bind integrin receptors present on the cell surface. However, cell biology research has illustrated that both integrin binding and integrin clustering are required to achieve a full adhesion response. This biophysical knowledge has motivated researchers to develop material systems biofunctionalized with nanoscale clusters of ligands that promote both integrin occupancy and clustering of the receptors. These materials have improved a wide variety of biological interactions in vitro including cell adhesion, proliferation, migration speed, gene expression, and stem cell differentiation; and improved in vivo outcomes including increased angiogenesis, tissue healing, and biomedical device integration. This review first introduces the techniques that enable the fabrication of these nanopatterned materials, describes the improved biological effects that have been achieved, and lastly discusses the current limitations of the technology and where future advances may occur. Although this technology is still in its nascency, it will undoubtedly play an important role in the future development of biomaterials and tissue engineering scaffolds for both in vitro and in vivo applications. Abstract : Functionalization of biomaterials with nanoscale clusters of integrin‐binding ligands is a powerful method of regulating adherent cell behaviour. However, the fabrication of such materials is not trivial. This review describes the techniques that have been developed to fabricate such materials; describes the improved biological properties of these materials, both in vitro and in vivo; and discusses future applications.