Pd nanosheets with their surface coordinated by radioactive iodide as a high-performance theranostic nanoagent for orthotopic hepatocellular carcinoma imaging and cancer therapy. Issue 18 (23rd April 2018)

• Record Type: Journal Article
• Authors: Chen, Mei; Guo, Zhide; Chen, Qinghua; Wei, Jingping; Li, Jingchao; Shi, Changrong; Xu, Duo; Zhou, Dawang; Zhang, Xianzhong; Zheng, Nanfeng
• Is Part Of: Chemical science. Volume 9:Issue 18(2018)
• Page Start: 4268
• Page End: 4274
• Publication Date: 2018-04-23
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8sc00104a
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : We report a pH-sensitive multifunctional theranostic platform with radiolabeled Pd nanosheets through a simple mixture of ultra-small Pd nanosheets and radioisotopes utilizing the specific adsorption of 131 I and 125 I on their surfaces. Abstract : Radiolabeled nanoparticles (NPs), taking advantage of nanotechnology and nuclear medicine, have shown attractive potential for cancer diagnosis and therapy. However, the high background signal in the liver and long-term toxic effects of radioisotopes caused by the nonselective accumulation of radiolabeled nanoparticles in organs have become the major challenges. Here, we report a pH-sensitive multifunctional theranostic platform with radiolabeled Pd nanosheets through a simple mixture of ultra-small Pd nanosheets and radioisotopes utilizing the strong adsorption of 131 I and 125 I on their surfaces (denoted as 131 I–Pd–PEG or 125 I–Pd–PEG). Systematic studies reveal that the labeling efficiency is higher than 98% and the adsorption of radioiodine is more stable in an acidic environment. In vivo studies further validate the pH-dependent behavior of this platform and the enhanced retention of radioisotopes in tumors due to the acidic microenvironment. Single photon emission computed tomography (SPECT) images with zero background were successfully achieved in a subcutaneous 4T1 tumor model, an orthotopic LM3 tumor model, and even in a Mst1/2 double-knockout hepatoma model. Moreover, the application of radiolabeled Pd nanosheets for photoacoustic (PA) imaging, and combined photothermal and radiotherapy was also explored. Therefore, this study provides a simple and efficient strategy to solve the critical high background issue of radiolabeled nanoparticles and shows enormous potential for clinical applications.