Bioassay‐Guided Isolation of Antifungal Compounds from Disporopsis aspersa (Hua) Engl. ex Diels against Pseudoperonospora cubensis and Phytophthora infestans. Issue 7 (21st June 2018)

• Record Type: Journal Article
• Authors: Zhu, Feng; Yuan, Chengshan; Gang, Fangli; Yang, Chaofu; Wu, Wenjun; Zhang, Jiwen
• Is Part Of: Chemistry & biodiversity. Volume 15:Issue 7(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-21
• Subjects: Disporopsis aspersa -- isolation -- fungicidal activity -- Pseudoperonospora cubensis -- Phytophthora infestans; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201800090
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : Oomycetes are one type of the most highly destructive of the diseases that cause damage to some important crop plants, such as potato late blight, cucumber downy mildew, and grape downy mildew. As main approach of the ongoing search for new botanical fungicide from plant, the secondary metabolites of D . aspersa were investigated. Through efficient bioassay‐guided isolation, two new (1 and2 ) and 12 known compounds (3 – 14 ) were isolated, and their structures were determined via extensive NMR, HR‐ESI‐MS, and IR. They were isolated from this genus for the first time except for compounds11 and12 . The biological properties of1 – 14 were evaluated against Pseudoperonospora cubensis and Phytophthora infestans . Compounds1 – 8 showed potent antifungal activity in vitro . Additionally, compound3 has preferable control effect on cucumber downy mildew, showing dual effect of protection and treatment in vivo . Abstract :