Rapid review shows that probiotics and fermented infant formulas do not cause d‐lactic acidosis in healthy children. (24th April 2018)

• Record Type: Journal Article
• Authors: Łukasik, J; Salminen, S; Szajewska, H
• Is Part Of: Acta pædiatrica. Volume 107:Number 8(2018)
• Page Start: 1322
• Page End: 1326
• Publication Date: 2018-04-24
• Subjects: Acidosis -- d‐lactic acid -- Fermented infant formulas -- Infant formulas -- Probiotics; Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.14338
• Languages: English
• ISSNs: 0803-5253

Abstract

Abstract: Aim: Extensive ongoing research on probiotics and infant formulas raises a number of safety questions. One concern is the potential influence ofd ‐lactic acid‐containing preparations on the health of infants and children. The aim of this review was to summarise the available knowledge on the ingestion ofd ‐lactic acid‐producing bacteria, acidified infant formulas and fermented infant formulas as a potential cause of paediatricd ‐lactic acidosis. Methods: A Medline database search was performed in July 2017, with no restrictions on the language, article type or publication date. The 1715 search results were screened for clinical trials, review articles, case series and case reports of relevance to the topic. Results: We identified five randomised controlled trials from 2005 to 2017 covering 544 healthy infants and some case reports and experimental studies. No clinically relevant adverse effects ofd ‐lactic acid‐producing probiotics and fermented infant formulas were described in healthy children. However, a harmless, subclinical accumulation ofd ‐lactate was theoretically possible. The only known cases of paediatricd ‐lactic acidosis occurred in patients with short bowel syndrome or, historically, in infants fed with acidified formulas. Conclusion: Our main finding was that probiotics and fermented formulas did not caused ‐lactic acidosis in healthy children.