Two new sesquiterpene lactones from leaves of yacon, Smallanthus sonchifolius. Issue 6 (3rd June 2018)

• Record Type: Journal Article
• Authors: Ran, Xiao-Ku; Win Aung, Khin Khin; Bai, Jun; Dou, Pei-Yuan; Zeng, Zheng; Dou, De-Qiang
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 6(2018)
• Page Start: 538
• Page End: 544
• Publication Date: 2018-06-03
• Subjects: NMR -- sesquiterpene lactones -- yacon -- chemical constituents -- Smallanthus sonchifolius; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1411346
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: The chemical constituents of 95% EtOH extract of yacon leaves were separated to yield two new sesquiterpene lactones, together with three known compounds. The two new compounds were characterized to be 8β-angeloyloxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester(1) and 8β-(3-methylbut-2-enoyl) oxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester(2) on the basis of NMR spectra, HR-MS and other spectroscopic methods. The cytotoxicity of compounds1–5 were evaluated on human hepatoma cell Bel-7402 and all the compounds showed moderate cytotoxicity. Abstract :