Two new thiophene polyacetylene glycosides from Atractylodes lancea. Issue 6 (3rd June 2018)

• Record Type: Journal Article
• Authors: Feng, Zi-Ming; Xu, Kuo; Wang, Wei; Du, Ning; Zhang, Jing-Hua; Yang, Ya-Nan; Jiang, Jian-Shuang; Zhang, Pei-Cheng
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 6(2018)
• Page Start: 531
• Page End: 537
• Publication Date: 2018-06-03
• Subjects: Asteraceae -- Atractylodes lancea -- thiophene polyacetylene -- atracthioenyneside A -- atracthioenyneside B -- absolute configuration; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1458841
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Phytochemical investigation on the rhizomes of Atractylodes lancea led to the isolation of two new thiophene polyacetylene glycosides (1 and2 ) and six known compounds (3 -8 ). Their structures were elucidated based on the extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of new compounds were established by calculated and experimental circular dichroism. All the compounds were assessed on the lipopolysaccharide-induced NO production in BV2 cells and compounds3, 7, and8 showed moderate inhibitory activities. Abstract :